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Antibody discovery and vaccine development research may be on the verge of rapidly expanding with data that previously took decades to acquire, thanks to LIBRA-seq, a new tool developed by Vanderbilt University researchers and their colleagues.

A computational method that uses hospital billing codes and electronic health records can identify genetic disease cases before clinical teams do.

Poorly functioning AMPARs have been linked to a wide range of neurological and psychiatric disorders including seizures, Alzheimer’s disease, major depression and autism spectrum disorder. Understanding how AMPARs are formed and operate is essential for the rational design of pharmacological compounds that, by tuning AMPAR activity up or down, could improve treatment of these conditions.

The identification of a protein important for insulin synthesis may hold clues for understanding the pathogenesis of diabetes.

To explore how fear becomes entrenched, VUMC researchers traveled down the precise neuronal pathways in the brains of mice that trigger fear responses, and which normally extinguish the behaviors once the danger has passed.

New study from neuroscientists at Vanderbilt provides initial answers to long-standing scientific questions on what causes the transition from moderate to compulsive alcohol consumption – and what makes some drinkers particularly vulnerable to developing alcohol use disorders. Read More

Researchers at VUMC have taken a major step that could ultimately facilitate development of a new class of antidepressants which may relieve symptoms more rapidly and effectively and with fewer side effects than current medications.

Obesity and two post-operative complications linked with it have associated genetic variants in common, suggesting that obesity may be the culprit.

Vanderbilt researchers have uncovered another piece in the puzzle of how cells divide — a process that goes awry in cancer cells.

Structural details of a protein that is essential to normal brain function could improve treatments for epilepsy and other seizure disorders.

Understanding how RSV is transmitted, which strains dominate and how new strains emerge around the globe will guide better vaccine and anti-viral drug design.

A novel tool developed by Vanderbilt scientists protects animals from endotoxin shock and can be used for mechanistic analyses of inflammation due to microbial and other insults.

Simulated electronic health records could avoid patient privacy risks and help speed discovery.

Interventions that impact the timing of recovery following acute injury may improve future outcomes for patients.

An unprecedented view of bacterial products within infected tissues opens new opportunities to explore infection biology and devise novel therapeutic strategies.

A diet high in fiber and yogurt is associated with a reduced risk for lung cancer, according to a study by Vanderbilt University Medical Center researchers.

Researchers at four institutions, including Vanderbilt, have been awarded a five-year, $9.4 million federal grant to tackle undiagnosed congenital diarrheas caused by a single gene mutation.

Early detection of lymphedema, which occurs in 20% of patients following breast cancer treatment, may improve therapeutic options for patients.

James Dewar and colleagues have identified a role for the enzyme topoisomerase II in reducing replication errors during the final stage of DNA synthesis.

Worm neurons have microscopic “spines” — where nerve-to-nerve communication happens — that share features with mammalian neurons, supporting the use of worms to study spine genetics and biology.