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Idiopathic subglottic stenosis is an unexplained narrowing of the windpipe just below the vocal cords. The disease is progressive, slowly affecting the patient’s ability to breathe, and can be fatal due to airway obstruction if left untreated.

More than half of patients with relapsed multiple myeloma treated with carfilzomib experienced cardiac issues during treatment, according to a multi-institutional study published June 12 in the Journal of Clinical Oncology.

Doctors formerly had to extract the malaria parasite’s DNA first, virtually impossible to do in rural, low-resource areas. Read More

Understanding how a steroid-metabolizing enzyme binds to its substrates may aid in designing drugs to treat sexual dysfunction as well as prostate cancer.

Scott Baldwin and colleagues have discovered early signaling events during heart development, findings that could guide cell replacement therapies for heart disease.

VUMC has joined an international effort to streamline and accelerate development of vaccines and other treatments against a growing worldwide surge of deadly and debilitating viral infections.

Microbial species in the mouth could be playing a role in colorectal cancer development, according to new research from epidemiologists at VUMC.

A new study published in Neurology reports the drug trofinetide has proven safe and effective in treating core symptoms of Rett syndrome in female children and adolescents.

A study from Vanderbilt’s Center for Biomedical Ethics and Society is bringing renewed focus on the concept of comprehension of informed consent for research purposes.

Vanderbilt University researchers have discovered how a protein pump distinguishes between chemicals that it will expel from a cell and inhibitors that block its action. The new findings could guide the development of more efficient inhibitors to prevent cancer cell resistance to chemotherapy.

The flu mutates so quickly that we need a new vaccine every year, but Vanderbilt scientists have found a vulnerable part of the virus that doesn't mutate as much.

Seasonal light exposure during pregnancy had effects on serotonin and depression that persisted into adulthood in mice. Read More

Basement membranes are important structural and functional components of tissues. New research provides insight into how they repair themselves.

New findings may speed progress toward programming cells to rebuild damaged hearts more quickly.

Benign lesions caused by a common fungus can mimic those caused by cancer in the lungs. A Vanderbilt research team is on the hunt for a non-invasive way for doctors to tell the two diseases apart. Read More

Asian countries are in the early stages of a tobacco smoking epidemic with habits mirroring those of the United States from past decades, setting the stage for a spike in future deaths from smoking-related diseases.

Using a unique computational framework they developed, a team of scientist cyber-sleuths in the Vanderbilt University Department of Molecular Physiology and Biophysics and the Vanderbilt Genetics Institute has identified 104 high-risk genes for schizophrenia.

Eric Skaar and colleagues have figured out how a common bug responsible for ventilator-associated pneumonia responds when starved of zinc, a metal it needs to survive, which may lead to new therapeutic targets for the dangerous infection.

A report by researchers at Vanderbilt University Medical Center has shattered conventional wisdom about how cells, including cancer cells, shed DNA into the bloodstream.

Jonathan Schoenecker, Stephanie Moore-Lotridge and colleagues have found a new target for treating a condition that causes bone to form in soft tissue, reducing mobility.